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GIP, or glucose-dependent insulinotropic polypeptide, is another gut hormone that enhances insulin response and plays a role in fat metabolism

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Tirzepatide (Zepbound/Mounjaro) produces more weight loss than semaglutide (Wegovy/Ozempic) at maximum doses: 20.2% vs 13.7% in the only head-to-head trial (SURMOUNT-5, NEJM 2025)